I'm triggered that lab research and clinical trials targeting the real goal of geroscience are being overshadowed by coffee raves and mindfulness retreats.
The distinction between improving health today and changing the biological trajectory is overdue, and Peakspan names something clinicians see constantly: function narrowing years before any diagnostic threshold is crossed. Living without a diagnosis is not the same as keeping your capacity. One nuance I'd add: some of that early loss is measurable now, not only in VO2 max or processing speed but in autonomic markers like recovery capacity and heart rate variability, which tend to drift well before disease does. That doesn't make stress management geroscience. But it could be a useful early readout while the harder biomedical work catches up.
The distinction between improving health today and changing the biological trajectory is overdue, and Peakspan names something clinicians see constantly: function narrowing years before any diagnostic threshold is crossed. Living without a diagnosis is not the same as keeping your capacity. One nuance I'd add: some of that early loss is measurable now, not only in VO2 max or processing speed but in autonomic markers like recovery capacity and heart rate variability, which tend to drift well before disease does. That doesn't make stress management geroscience. But it could be a useful early readout while the harder biomedical work catches up.
💯 totally agree
But how do we radicalize (aka allow thinking and talking about more ambitious goals) more people?